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Identification of Virulence Factors Involved in a Murine Model of Severe Achromobacter xylosoxidans Infection

31 May 2023

Abstract excerpt

, mice challenged with GN050 had fewer macrophages. Mutants with transposon insertions in predicted virulence factors of GN050 showed that disease severity depended on the type III secretion system, Vi capsule, antisigma-E factor, and partially on the ArtA adhesin. The development of an acute infection model provides an essential tool to better understand the infectivity of diverse Ax isolates and enable improved...

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PMID: 37255468
DOI: 10.1128/iai.00037-23

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