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Epigenetic modifications in radiation-induced non-targeted effects and their clinical significance

23 May 2023

Abstract excerpt

BACKGROUND: Ionizing radiation (IR) plays an important role in the diagnosis and treatment of cancer. Besides the targeted effects, the non-targeted effects, which cause damage to non-irradiated cells and genomic instability in normal tissues, also play a role in the side effects of radiotherapy and have been shown to involve both alterations in DNA sequence and regulation of epigenetic modifications. SCOPE OF...

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PMID: 37230420
DOI: 10.1016/j.bbagen.2023.130386

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