Article
Identification of a novel downstream binding protein implicated in late-phase-specific activation of the adenovirus major late promotor.
Nucleic acids research - 11 Aug 1992
Mondesert G, Tribouley C, Kedinger C
Abstract excerpt
The adenovirus major late promotor (MLP) is induced to very high levels after the onset of the viral DNA replication. Previous studies have identified sequence elements located downstream of the MLP startsite (DE1, between +85 and +98; DE2, between +100 and +120) implicated, together with the upstream promoter element, in this late-phase-specific transcriptional activation. One protein (DEF, now renamed DEF-A),...
Topics
- Adenoviridae
- Base Sequence
- Cell Extracts
- DNA-Binding Proteins
- Electrophoresis
- Gene Expression Regulation, Viral
- HeLa Cells
- Humans
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic