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Article

Photoreceptor Cell-Derived CAPN5 Regulates Retinal Pigment Epithelium Cell Proliferation Through Direct Regulation of SLIT2 Cleavage.

Investigative ophthalmology & visual science - 1 Apr 2018

Wang Yan, Li Heming, Zang Shihu, Li Fanfan, Chen Yingying, Zhang Xiao, Song Zongming, Peng Qing, Gu Feng

Abstract excerpt

Purpose: To identify the causative gene and investigate the corresponding mechanisms for an autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV) family. Methods: Clinical examination and genetic analysis were performed in a Chinese ADNIV family. To dissect the molecular consequence, we used gene targeting to knock-in a patient's specific mutation in the mouse genome. Immunostaining and...

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Source

Identifiers

PMID: 29610848
DOI: 10.1167/iovs.17-22689

Genes

SLIT2
CAPN5
RPE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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