Article
Recombinant human adenovirus type 5 based vaccine candidates against GIIa- and GIIb-genotype porcine epidemic diarrhea virus induce robust humoral and cellular response in mice.
Virology - 1 Jul 2023
Miao Xin, Zhang Liping, Zhou Peng, Zhang Zhongwang, Yu Ruiming, Liu Xiaoqing, Lv Jianliang, Wang Yonglu, Guo Huichen, Pan Li, Liu Xinsheng
Abstract excerpt
Porcine epidemic diarrhea virus (PEDV) is a porcine enteropathogenic coronavirus causing severe watery diarrhea, vomiting, dehydration, and death in piglets. However, most commercial vaccines are developed based on the GI genotype strains, and have poor immune protection against the currently dominant GII genotype strains. Therefore, four novel replication-deficient human adenovirus 5-vectored vaccines expressing...
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