Article
Diversity of cervicovaginal human papillomavirus (HPV) genotypes and naturally occurring E6/E7 DNA polymorphisms of HPV-16 in Ghana.
Tumour virus research - 1 Jun 2023
Kaba Gladys, Stevenson Andrew, Sakyi Samuel Asamoah, Konney Thomas Okpoti, Bhatia Ramya, Titiloye Nicholas A, Oppong Samuel A, Agyemang-Yeboah Francis, Cuschieri Kate, Graham Sheila V
Abstract excerpt
Human papillomavirus (HPV) E6 and E7 oncogene expression is essential for cervical carcinogenesis. Evidence exists that E6/E7 variants may have different transforming activities while the risk of HPV-16 variants (A/D) differs by race/ethnicity. We determined the type-specific diversity of HPV infection in women with high grade cervical disease or cervical cancer in Ghana and investigated naturally occurring E6/E7...
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