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Article

Declining autozygosity over time: An exploration in over 1 million individuals from three diverse cohorts.

American journal of human genetics - 1 Jun 2023

Colbert Sarah M C, Wendt Frank R, Pathak Gita A, Helmer Drew A, Hauser Elizabeth R, Keller Matthew C, Polimanti Renato, Johnson Emma C

Abstract excerpt

Previous studies have hypothesized that autozygosity is decreasing over generational time. However, these studies were limited to relatively small samples (n < 11,000) lacking in diversity, which may limit the generalizability of their findings. We present data that partially support this hypothesis from three large cohorts of diverse ancestries, two from the US (All of Us, n = 82,474; the Million Veteran...

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Identifiers

PMID: 37178685
DOI: 10.1016/j.ajhg.2023.04.007
PMCID: PMC10257001

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