Article
Fetal Loss in Pregnant Rabbits Infected with Genotype 3 Hepatitis E Virus Is Associated with Altered Inflammatory Responses, Enhanced Virus Replication, and Extrahepatic Virus Dissemination with Positive Correlations with Increased Estradiol Level.
mBio - 25 Apr 2023
Mahsoub Hassan M, Heffron C Lynn, Hassebroek Anna M, Sooryanarain Harini, Wang Bo, LeRoith Tanya, Rodríguez Guillermo Raimundi, Tian Debin, Meng Xiang-Jin
Abstract excerpt
Hepatitis E virus (HEV) causes adverse clinical outcomes in pregnant women, but the underlying mechanisms remain poorly understood. To delineate the mechanisms of pregnancy-associated adverse effects during HEV infection, we utilized a genotype 3 HEV from rabbit (HEV-3ra) and its cognate host (rabbits) to systematically investigate the clinical consequences, viral replication dynamics, and host immune and...
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