Gene copy number variation and pediatric mental health/neurodevelopment in a general population.

doi:10.1093/hmg/ddad074

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Article

Gene copy number variation and pediatric mental health/neurodevelopment in a general population.

Human molecular genetics - 20 Jul 2023

Zarrei Mehdi, Burton Christie L, Engchuan Worrawat, Higginbotham Edward J, Wei John, Shaikh Sabah, Roslin Nicole M, MacDonald Jeffrey R, Pellecchia Giovanna, Nalpathamkalam Thomas, Lamoureux Sylvia, Manshaei Roozbeh, Howe Jennifer, Trost Brett, Thiruvahindrapuram Bhooma, Marshall Christian R, Yuen Ryan K C, Wintle Richard F, Strug Lisa J, Stavropoulos Dimitri J, Vorstman Jacob A S, Arnold Paul, Merico Daniele, Woodbury-Smith Marc, Crosbie Jennifer, Schachar Russell J, Scherer Stephen W

Abstract excerpt

We assessed the relationship of gene copy number variation (CNV) in mental health/neurodevelopmental traits and diagnoses, physical health and cognition in a community sample of 7100 unrelated children and youth of European or East Asian ancestry (Spit for Science). Clinically significant or susceptibility CNVs were present in 3.9% of participants and were associated with elevated scores on a continuous measure...

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Identifiers

PMID: 37154571
DOI: 10.1093/hmg/ddad074
PMCID: PMC10360394

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