Impact of the MCP-1-2518A>G polymorphism on COVID-19 severity in the Iranian population: A case-control study.

doi:10.1016/j.intimp.2023.110217

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Article

Impact of the MCP-1-2518A>G polymorphism on COVID-19 severity in the Iranian population: A case-control study.

International immunopharmacology - 1 Jun 2023

Mohammadi Niki Ghambari, Namaki Saeed, Hashemi Seyed Mahmoud, Salehi Mohammadreza, Ghaffarpour Sara, Ghazanfari Tooba

Abstract excerpt

As a result of SARS-CoV-2 infection, the host's immune system is disrupted, and chemokines and cytokines are intensified to eliminate the virus, resulting in cytokine storm syndrome and acute respiratory distress syndrome (ARDS). Patients with COVID-19 have been observed to have elevated levels of MCP-1, a chemokine associated with the severity of the disease. In some diseases, polymorphisms in the regulatory...

Topics

Humans
Case-Control Studies
Chemokine CCL2
COVID-19
Genetic Predisposition to Disease
Genotype
Iran
Polymorphism, Single Nucleotide
SARS-CoV-2

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Identifiers

PMID: 37148770
DOI: 10.1016/j.intimp.2023.110217
PMCID: PMC10123354

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