Article
The G allele of SNP rs3922 reduces the binding affinity between IGF2BP3 and CXCR5 correlating with a lower antibody production.
European journal of immunology - 1 Aug 2023
Duan Zhaojun, Ma Longfei, Jin Jing, Ma Lingyu, Ye Lilin, Wu Jianguo, Luo Yunping
Abstract excerpt
Effective vaccines that function through humoral immunity seek to produce high-affinity antibodies. Our previous research identified the single-nucleotide polymorphism rs3922G in the 3'UTR of CXCR5 as being associated with nonresponsiveness to the hepatitis B vaccine. The differential expression of CXCR5 between the dark zone (DZ) and light zone (LZ) is critical for organizing the functional structure of the...
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