Article
Identification of a Common Variant for Coronary Heart Disease at PDE1A Contributes to Individualized Treatment Goals and Risk Stratification of Cardiovascular Complications in Chinese Patients With Type 2 Diabetes.
Diabetes care - 1 Jun 2023
Tam Claudia H T, Lim Cadmon K P, Luk Andrea O Y, Shi Mai, Man Cheung Hoi, Ng Alex C W, Lee Heung-Man, Lau Eric S H, Fan Baoqi, Jiang Guozhi, Kong Alice P S, Ozaki Risa, Chow Elaine Y K, Lee Ka Fai, Siu Shing Chung, Hui Grace, Tsang Chiu Chi, Lau Kam Piu, Leung Jenny Y Y, Cheung Elaine Y N, Tsang Man Wo, Kam Grace, Lau Ip Tim, Li June K Y, Yeung Vincent T F, Lau Emmy, Lo Stanley, Fung Samuel, Cheng Yuk Lun, Chow Chun Chung, Fan Xiaodan, Chan Ting Fung, Yip Kevin Y L, Lok Si, Yu Weichuan, Tsui Stephen K W, Lan Hui-Yao, Szeto Cheuk Chun, Tang Nelson L S, Tomlinson Brian, Huang Yu, Jenkins Alicia J, Keech Anthony, So Wing-Yee, Chan Juliana C N, Ma Ronald C W
Abstract excerpt
OBJECTIVE: In this study we aim to unravel genetic determinants of coronary heart disease (CHD) in type 2 diabetes (T2D) and explore their applications. RESEARCH DESIGN AND METHODS: We performed a two-stage genome-wide association study for CHD in Chinese patients with T2D (3,596 case and 8,898 control subjects), followed by replications in European patients with T2D (764 case and 4,276 control subjects) and...
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