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MicroRNA-21 and microRNA-148a affects PTEN, NO and ROS in canine leishmaniasis

13 Apr 2023

Abstract excerpt

Canine Visceral leishmaniasis (CanL) poses a severe public health threat in several countries. Disease progression depends on the degree of immune response suppression. MicroRNAs (miRs) modulate mRNA translation into proteins and regulate various cellular functions and pathways associated with immune responses. MiR-21 and miR-148a can alter the parasite load and M1 macrophages are the principal cells in dogs’...

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PMID: 37124626
DOI: 10.3389/fgene.2023.1106496

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