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Identifying Lymph Node Metastasis-Related Factors in Breast Cancer Using Differential Modular and Mutational Structural Analysis.

Interdisciplinary sciences, computational life sciences - 1 Dec 2023

Liu Xingyi, Yang Bin, Huang Xinpeng, Yan Wenying, Zhang Yujuan, Hu Guang

Abstract excerpt

Complex diseases are generally caused by disorders of biological networks and/or mutations in multiple genes. Comparisons of network topologies between different disease states can highlight key factors in their dynamic processes. Here, we propose a differential modular analysis approach that integrates protein-protein interactions with gene expression profiles for modular analysis, and introduces inter-modular...

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PMID: 37115388
DOI: 10.1007/s12539-023-00568-w

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RET

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