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Quantifying requirements for mitochondrial apoptosis in CAR T killing of cancer cells

13 Apr 2023

Abstract excerpt

Chimeric antigen receptor (CAR) T cell therapy is an FDA-approved treatment for several hematologic malignancies, yet not all patients respond to this treatment. While some resistance mechanisms have been identified, cell death pathways in target cancer cells remain underexplored. Impairing mitochondrial apoptosis via knockout of Bak and Bax, forced Bcl-2 and Bcl-XL expression, or caspase inhibition protected...

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PMID: 37055388
DOI: 10.1038/s41419-023-05727-x

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