Article
Evidence Linking PPARG Genetic Variants with Periodontitis and Type 2 Diabetes Mellitus in a Brazilian Population.
International journal of molecular sciences - 5 Apr 2023
Cirelli Thamiris, Nicchio Ingra G, Bussaneli Diego G, Silva Bárbara R, Nepomuceno Rafael, Orrico Silvana R P, Cirelli Joni A, Theodoro Letícia H, Barros Silvana P, Scarel-Caminaga Raquel M
Abstract excerpt
The peroxisome proliferator-activated receptor gamma (PPARG) gene encodes a transcription factor involved in the regulation of complex metabolic and inflammatory diseases. We investigated whether single nucleotide polymorphisms (SNPs) and haplotypes of the PPARG gene could contribute with susceptibility to develop periodontitis alone or together with type 2 diabetes mellitus (T2DM). Moreover, we evaluated the...
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