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Optical Genome Mapping in Routine Cytogenetic Diagnosis of Acute Leukemia

3 Apr 2023

Abstract excerpt

Cytogenetic aberrations are found in 65% of adults and 75% of children with acute leukemia. Specific aberrations are used as markers for the prognostic stratification of patients. The current standard cytogenetic procedure for acute leukemias is karyotyping in combination with FISH and RT-PCR. Optical genome mapping (OGM) is a new technology providing a precise identification of chromosomal abnormalities in a...

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PMID: 37046792
DOI: 10.3390/cancers15072131

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