Article
Optical genome mapping, a promising alternative to gold standard cytogenetic approaches in a series of acute lymphoblastic leukemias.
Genes, chromosomes & cancer - 1 Oct 2021
Lestringant Valentin, Duployez Nicolas, Penther Dominique, Luquet Isabelle, Derrieux Coralie, Lutun Anne, Preudhomme Claude, West Michaela, Ouled-Haddou Hakim, Devoldere Catherine, Marolleau Jean-Pierre, Garçon Loïc, Jedraszak Guillaume, Ferret Yann
Abstract excerpt
Acute lymphoblastic leukemias (ALL) are characterized by a large number of cytogenetic abnormalities of clinical interest that require the use of several complementary techniques. Optical genome mapping (OGM) is based on analysis of ultra-high molecular weight DNA molecules that provides a high-resolution genome-wide analysis highlighting copy number and structural anomalies, including balanced translocations. We...
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