Article
A glycan epitope correlates with tau in serum and predicts progression to Alzheimer's disease in combination with APOE4 allele status.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jul 2023
Zhou Robin Ziyue, Vetrano Davide Liborio, Grande Giulia, Duell Frida, Jönsson Linus, Laukka Erika J, Fredolini Claudia, Winblad Bengt, Tjernberg Lars, Schedin-Weiss Sophia
Abstract excerpt
INTRODUCTION: There is an urgent need for novel blood biomarkers for the detection of Alzheimer's disease (AD). We previously showed that levels of the bisecting N-acetylglucosamine glycan epitope was elevated in cerebrospinal fluid in AD. However, its diagnostic value in blood is unknown. METHODS: We analyzed blood levels of bisecting N-acetylglucosamine and total tau in a retrospective cohort of 233...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.