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Immune Profiling Reveals Decreases in Circulating Regulatory and Exhausted T Cells in Human Hypertension

4 Jan 2023

Abstract excerpt

Evidence from nonhuman animal models demonstrates an important role for immune cells in hypertension, but immune cell changes in human hypertension are less clear. Using mass cytometry, we demonstrate novel and selective reductions in CCR10+ regulatory T cells (Tregs) and PD-1+CD57−CD8+ memory T cells. RNA sequencing reveals that CCR10+ Tregs exhibit gene expression changes consistent with enhanced...

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PMID: 37034287
DOI: 10.1016/j.jacbts.2022.09.007

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