Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pleiotropy promotes the evolution of inducible immune responses in a model of host-pathogen coevolution.

PLoS computational biology - 1 Apr 2023

Martin Reese A, Tate Ann T

Abstract excerpt

Components of immune systems face significant selective pressure to efficiently use organismal resources, mitigate infection, and resist parasitic manipulation. A theoretically optimal immune defense balances investment in constitutive and inducible immune components depending on the kinds of parasites encountered, but genetic and dynamic constraints can force deviation away from theoretical optima. One such...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Evolution
Share to Genetic Pleiotropy
Share to Immunity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Parasites

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 37022993
DOI: 10.1371/journal.pcbi.1010445
PMCID: PMC10079112

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pleiotropy promotes the evolution of inducible immune responses in a model of host-pathogen coevolution.PMID 37022993Read ↗

Coevolutionary feedback elevates constitutive immune defence: a protein network model.Semantic proximity Read ↗

Predicting pathogen mutual invasibility and co-circulationSemantic proximity Read ↗

Antigenic diversity, transmission mechanisms, and the evolution of pathogens.Semantic proximity Read ↗

ON THE EVOLUTIONARY DYNAMICS OF PATHOGENS WITH DIRECT AND ENVIRONMENTAL TRANSMISSIONSemantic proximity Read ↗

Acute or Chronic? Within‐Host Models with Immune Dynamics, Infection Outcome, and Parasite EvolutionSemantic proximity Read ↗

Antagonistic pleiotropy involving promoter sequences in a virus.Semantic proximity Read ↗

Evolution of parasite virulence when host responses cause diseaseSemantic proximity Read ↗

Signatures of selection in pleiotropic genes involved in insect neuronal and immune systemsSemantic proximity Read ↗

The evolution of constitutive and induced defences to infectious diseaseSemantic proximity Read ↗

Emerging viruses: why they are not jacks of all trades?Semantic proximity Read ↗

The interplay between host community structure and pathogen life‐history constraints in driving the evolution of host‐range shiftsSemantic proximity Read ↗

Virulence evolution via pleiotropy in vector-borne plant pathogens.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.