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Native human zona pellucida glycoproteins: purification and binding properties

10 Mar 2008

Abstract excerpt

BACKGROUND: Fertilization starts with the binding of the spermatozoa to the zona pellucida (ZP) of the oocyte. Such binding is a carbohydrate-mediated event and consists of a series of tightly regulated events. Molecular interactions between spermatozoon and ZP in human are not well characterized due to limited availability of oocytes for research. Our current technology cannot generate recombinant human ZP (hZP)...

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PMID: 18332087
DOI: 10.1093/humrep/den047

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