Article
XRCC3 and NBS1 gene polymorphisms modulate the risk of pre-oral cancer and oral cancer in the North Indian population.
Journal of cancer research and therapeutics - 1 Jan 2000
Nigam Kumud, Gupta Shalini, Singh Navin, Yadav Suresh Kumar, Sanyal Somali
Abstract excerpt
Background: Oral cancer is alarming disease in the developing countries like India. DNA repair capacity may affect by genetic polymorphisms in DNA repair genes and thus may cause to cancer. XRCC3 involves in homologous recombination repair pathway and repair DNA damage and crosslinks while, NBS1 participate in repair of double strand DNA break and starts the cell-cycle checkpoint signaling. Aims and Objectives:...
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