Article
Efficacy of Dolutegravir versus Darunavir in Antiretroviral First-Line Regimens According to Resistance Mutations and Viral Subtype.
Viruses - 16 Mar 2023
Salvo Pierluigi Francesco, Farinacci Damiano, Ciccullo Arturo, Borghi Vanni, Rusconi Stefano, Saracino Annalisa, Gennari William, Bruzzone Bianca, Vicenti Ilaria, Callegaro Annapaola, Di Biagio Antonio, Zazzi Maurizio, Di Giambenedetto Simona, Borghetti Alberto
Abstract excerpt
BACKGROUND: Dolutegravir (DTG)-based first-line regimens have shown superior efficacy versus darunavir (DRV)-based ones in randomized trials. We compared these two strategies in clinical practice, particularly considering the role of pre-treatment drug resistance mutations (DRMs) and of the HIV-1 subtype. MATERIALS AND METHODS: The multicenter Antiretroviral Resistance Cohort Analysis (ARCA) database was queried...
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