Transcriptomics-Based Subphenotyping of the Human Placenta Enabled by Weighted Correlation Network Analysis in Early-Onset Preeclampsia With and Without Fetal Growth Restriction

Abstract excerpt

Background: Placental disorders contribute to pregnancy complications, including preeclampsia and fetal growth restriction (FGR), but debate regarding their specific pathobiology persists. Our objective was to apply transcriptomics with weighted gene correlation network analysis to further clarify the placental dysfunction in these conditions. Methods: We performed RNA sequencing with weighted gene correlation...

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• Share to Maternal and fetal healthcare
• Share to Pregnancy and preeclampsia studies
• Share to Preterm Birth and Chorioamnionitis