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Article

A NOTCH1 Mutation Found in a Newly Established Ovarian Cancer Cell Line (FDOVL) Promotes Lymph Node Metastasis in Ovarian Cancer.

International journal of molecular sciences - 7 Mar 2023

Jiang Wei, Ouyang Xueyan, Jiang Chunjuan, Yin Lina, Yao Qianlan, Pei Xuan, Ji Zhaodong, Li Ming, Song Shaoli, Yang Wentao, Huang Shenglin, Yang Huijuan, Shan Boer

Abstract excerpt

Peritoneal implantation and lymph node metastasis have different driving mechanisms in ovarian cancer. Elucidating the underlying mechanism of lymph node metastasis is important for treatment outcomes. A new cell line, FDOVL, was established from a metastatic lymph node of a patient with primary platinum-resistant ovarian cancer and was then characterized. The effect of NOTCH1-p.C702fs mutation and NOTCH1...

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Share to Carcinoma, Ovarian Epithelial
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymph Nodes

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Identifiers

PMID: 36982170
DOI: 10.3390/ijms24065091
PMCID: PMC10049685

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