Article
Polymorphisms of the hypothalamic-pituitary-adrenal axis may lead to an inadequate response to stress and contribute to sudden infant death syndrome.
Acta paediatrica (Oslo, Norway : 1992) - 1 Jul 2023
Uzuntas Elanur, Schürmann Peter, Rothämel Thomas, Dörk Thilo, Klintschar Michael
Abstract excerpt
AIM: Impaired resilience to stress may be a factor in sudden infant death syndrome (SIDS). However, no comprehensive studies have been performed on polymorphisms that are relevant to the hypothalamic-pituitary-adrenal (HPA) axis, which regulates the stress hormone cortisol. METHODS: We analysed 22 relevant single nucleotide polymorphisms (SNPs) in 206 anonymised SIDS cases who died at a mean of 131 days (range:...
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