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CMPK2 is a host restriction factor that inhibits infection of multiple coronaviruses in a cell-intrinsic manner

17 Mar 2023

Abstract excerpt

Coronaviruses (CoVs) comprise a group of important human and animal pathogens. Despite extensive research in the past 3 years, the host innate immune defense mechanisms against CoVs remain incompletely understood, limiting the development of effective antivirals and non-antibody-based therapeutics. Here, we performed an integrated transcriptomic analysis of porcine jejunal epithelial cells infected with porcine...

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PMID: 36930652
DOI: 10.1371/journal.pbio.3002039

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