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Core genome sequencing and genotyping of Leptospira interrogans in clinical samples by target capture sequencing.

BMC infectious diseases - 14 Mar 2023

Grillova Linda, Cokelaer Thomas, Mariet Jean-François, da Fonseca Juliana Pipoli, Picardeau Mathieu

Abstract excerpt

BACKGROUND: The life-threatening pathogen Leptospira interrogans is the most common agent of leptospirosis, an emerging zoonotic disease. However, little is known about the strains that are currently circulating worldwide due to the fastidious nature of the bacteria and the difficulty to isolate cultures. In addition, the paucity of bacteria in blood and other clinical samples has proven to be a considerable...

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PMID: 36918832
DOI: 10.1186/s12879-023-08126-x
PMCID: PMC10012794

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