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Genomic comparison of Leptospira interrogans isolated from humans, dogs, and wild and feral animals in Japan.

International journal of medical microbiology : IJMM - 1 Jun 2026

Kakita Tetsuya, Takabe Kyosuke, Morita Masatomo, Okano Sho, Taira Katsuya, Kudeken Tsuyoshi, Taira Haruno, Kyan Hisako, Shinya So, Murata Ryo, Akeda Yukihiro, Ohnishi Makoto, Koizumi Nobuo

Abstract excerpt

Leptospirosis, caused by pathogenic Leptospira spp., is one of the most prevalent zoonotic diseases worldwide. While whole genome sequencing (WGS) has revealed global genetic diversity of Leptospira spp., large-scale genomic comparisons between human and animal isolates remain limited, and their epidemiological relationships are not fully understood. In this study, we performed WGS on 204 Leptospira isolates...

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PMID: 41579465
DOI: 10.1016/j.ijmm.2026.151702

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