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Article

Boosting of Voriconazole Levels With Omeprazole, A CYP450 2C19 Inhibitor.

The Pediatric infectious disease journal - 1 Jun 2023

Hsu Alice J, Lee Carlton K K, McAteer John, Zhang Sean X, Tamma Pranita D

Abstract excerpt

Children metabolize voriconazole faster than adults and require higher weight-based doses and more frequent administration to achieve therapeutic troughs. We report a case of a 4-year-old girl with disseminated fusariosis with persistently undetectable voriconazole troughs. Omeprazole was added as a CYP2C19-inhibitor to increase voriconazole concentrations. This case highlights the role of omeprazole for...

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Identifiers

PMID: 36916862
DOI: 10.1097/INF.0000000000003898
PMCID: PMC10198811

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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