Article
Downregulated FGFR3 Expression Inhibits In Vitro Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells of Mice with TBXT Gene Mutation.
Bulletin of experimental biology and medicine - 1 Feb 2023
Su H, Yang G, Yang H X, Liu M N, Li X D, Chen L, Li Y, Wang D Q, Ma T, Song Y L, Li H J, Du C G, Li X H, Cao G F
Abstract excerpt
We studied the effect of fibroblast growth factor receptor 3 (FGFR3) inhibitor BGJ-398 on the differentiation of bone marrow mesenchymal stem cells (BM MSC) into osteoblasts in wild type (wt) mice and in animals with mutation in TBXT gene (mt) and possible differences in the pluripotency of these cells. Cytology tests showed that the cultured BM MSC could differentiate into osteoblasts and adipocytes. The effect...
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