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Article

A c-Myc-regulated stem cell-like signature in high-risk neuroblastoma: A systematic discovery (Target neuroblastoma ESC-like signature).

Scientific reports - 3 Mar 2017

Yang Xinan Holly, Tang Fangming, Shin Jisu, Cunningham John M

Abstract excerpt

c-Myc dysregulation is hypothesized to account for the 'stemness' - self-renewal and pluripotency - shared between embryonic stem cells (ESCs) and adult aggressive tumours. High-risk neuroblastoma (HR-NB) is the most frequent, aggressive, extracranial solid tumour in childhood. Using HR-NB as a platform, we performed a network analysis of transcriptome data and presented a c-Myc subnetwork enriched for genes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28246384
DOI: 10.1038/s41598-017-00122-x
PMCID: PMC5427913

Genes

CDK2
CCND1
CDKN3

Provenance

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