Article
Bone marrow-derived dedifferentiated fat cells exhibit similar phenotype as bone marrow mesenchymal stem cells with high osteogenic differentiation and bone regeneration ability.
Journal of orthopaedic surgery and research - 11 Mar 2023
Sawada Hirokatsu, Kazama Tomohiko, Nagaoka Yuki, Arai Yoshinori, Kano Koichiro, Uei Hiroshi, Tokuhashi Yasuaki, Nakanishi Kazuyoshi, Matsumoto Taro
Abstract excerpt
BACKGROUND: Mesenchymal stem cells (MSCs) are known to have different differentiation potential depending on the tissue of origin. Dedifferentiated fat cells (DFATs) are MSC-like multipotent cells that can be prepared from mature adipocytes by ceiling culture method. It is still unknown whether DFATs derived from adipocytes in different tissue showed different phenotype and functional properties. In the present...
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