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The salivary protein Saglin facilitates efficient midgut colonization of Anopheles mosquitoes by malaria parasites

2 Mar 2023

Abstract excerpt

Malaria is caused by the unicellular parasite Plasmodium which is transmitted to humans through the bite of infected female Anopheles mosquitoes. To initiate sexual reproduction and to infect the midgut of the mosquito, Plasmodium gametocytes are able to recognize the intestinal environment after being ingested during blood feeding. A shift in temperature, pH change and the presence of the insect-specific...

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PMID: 36862755
DOI: 10.1371/journal.ppat.1010538

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