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Article

Complete sequencing of a cynomolgus macaque major histocompatibility complex haplotype.

Genome research - 1 Mar 2023

Karl Julie A, Prall Trent M, Bussan Hailey E, Varghese Joshua M, Pal Aparna, Wiseman Roger W, O'Connor David H

Abstract excerpt

Macaques provide the most widely used nonhuman primate models for studying the immunology and pathogenesis of human diseases. Although the macaque major histocompatibility complex (MHC) region shares most features with the human leukocyte antigen (HLA) region, macaques have an expanded repertoire of MHC class I genes. Although a chimera of two rhesus macaque MHC haplotypes was first published in 2004, the...

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PMID: 36854669
DOI: 10.1101/gr.277429.122
PMCID: PMC10078292

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