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A heterozygous missense variant in DLX3 leads to uterine leiomyomas and pregnancy losses in a consanguineous Iranian family.

Gene - 20 May 2023

Saboori-Darabi Samaneh, Carrera Paola, Akbari Arvand, Amiri-Yekta Amir, Almadani Navid, Battista Pipitone Giovanni, Shahrokh-Tehraninejad Ensieh, Lotfi Marzieh, Mazaheri Mahta, Totonchi Mehdi

Abstract excerpt

Uterine leiomyomas (ULs) are benign solid tumors arising from the uterine myometrium. They are the most common pelvic tumors among females of reproductive age. Despite the universal prevalence of ULs and its huge impact on women's lives, the exact etiology and pathophysiologic mechanisms have not been fully understood. Numerous studies indicate that genetic factors play a crucial role in ULs development. This...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36854347
DOI: 10.1016/j.gene.2023.147292

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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