Erp and Rev Adhesins of the Lyme Disease Spirochete’s Ubiquitous cp32 Prophages Assist the Bacterium during Vertebrate Infection

Abstract excerpt

kb (cp32s). The cp32s of Lyme agents are particularly unique in that they encode two distinct families of lipoproteins, namely, Erp and Rev, that are expressed on the bacterial outer surface during infection of vertebrate hosts. All identified functions of those outer surface proteins involve interactions between the spirochetes and host molecules, as follows: Erp proteins bind plasmin(ogen), laminin,...

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