Article
An Optimized Search Prognosis Tool to Predict 8/8 HLA Allele-Matched Unrelated Donor Procurement.
Transplantation and cellular therapy - 1 May 2023
Davis Eric, Archer Anne, Flynn Jessica, Nhaissi Melissa, Rapoport Candice, Suri Beth, Wells Deborah, Papadopoulos Esperanza, Politikos Ioannis, Fingrut Warren B, Scaradavou Andromachi, Barker Juliet N
Abstract excerpt
For patients in need of allogeneic transplantation who lack an HLA-identical sibling, an 8/8 HLA allele-matched unrelated donor (URD) is a standard alternative. However, delays in URD procurement can adversely impact patient care. Recipient genotype and search assessment (MSKv1.0)-based tools can predict search prognosis for many, but both tools have lower performance in non-European ancestry patients. Using the...
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