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FANCD2 inhibits ferroptosis by regulating the JAK2/STAT3 pathway in osteosarcoma

22 Feb 2023

Abstract excerpt

Abstract Background This research aimed to investigate the roles of fanconi anemia complementation group D2 (FANCD2) on the regulation of ferroptosis in osteosarcoma progression. Methods The function of FANCD2 on cell viability, invasion, migration, and tumor growth were explored. FANCD2 and pathway-related genes were determined by western blot. Ferroptosis-associated markers were determined, including lipid...

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PMID: 36814203
DOI: 10.1186/s12885-023-10626-7

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