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Article

Significant Association of Poly-A and Fok1 Polymorphic Alleles of the Vitamin D Receptor with Vitamin D Serum Levels and Incidence of Squamous Cutaneous Neoplasia.

The Journal of investigative dermatology - 1 Aug 2023

Bullock Taylor A, Mack Judith A, Negrey Jeffrey, Kaw Urvashi, Hu Bo, Anand Sanjay, Hasan Tayyaba, Warren Christine B, Maytin Edward V

Abstract excerpt

Vitamin D3, a prohormone, is converted to circulating calcidiol and then to calcitriol, the hormone that binds to the vitamin D receptor (VDR) (a nuclear transcription factor). Polymorphic genetic sequence variants of the VDR are associated with an increased risk of breast cancer and melanoma. However, the relationship between VDR allelic variants and the risk of squamous cell carcinoma and actinic keratosis...

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Identifiers

PMID: 36813159
DOI: 10.1016/j.jid.2023.01.028
PMCID: PMC10439970

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Significant Association of Poly-A and Fok1 Polymorphic Alleles of the Vitamin D Receptor with Vitamin D Serum Levels and Incidence of Squamous Cutaneous Neoplasia.PMID 36813159Read ↗

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