Article
Comprehensive profiling of EGFR mutation subtypes reveals genomic-clinical associations in non-small-cell lung cancer patients on first-generation EGFR inhibitors.
Neoplasia (New York, N.Y.) - 1 Apr 2023
Bai Yongkang, Liu Xiang, Zheng Limin, Wang Song, Zhang Junli, Xiong Shi, Zhang Pengfei, Jiao Zichen, Zhao Gefei, Zhou Chu, Pang Jiaohui, Xu Yang, Ou Qiuxiang, Mao Yuan, Zhang Louqian
Abstract excerpt
Common sensitizing mutations in epidermal growth factor receptor (cEGFR), including exon 19 deletions (19-Del) and exon 21 L858R substitution, are associated with high sensitivity to EGFR-TKIs in NSCLC patients. The treatment for NSCLC patients with uncommon EGFR (uEGFR) mutations remains a subject of debate due to heterogeneity in treatment responses. In this manuscript, the targeted next-generation sequencing...
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