Erlotinib alone or with bevacizumab as first-line therapy in patients with advanced non-squamous non-small-cell lung cancer harbouring EGFR mutations (JO25567): an open-label, randomised, multicentre, phase 2 study.

doi:10.1016/S1470-2045(14)70381-X

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Erlotinib alone or with bevacizumab as first-line therapy in patients with advanced non-squamous non-small-cell lung cancer harbouring EGFR mutations (JO25567): an open-label, randomised, multicentre, phase 2 study.

The Lancet. Oncology - 1 Oct 2014

Seto Takashi, Kato Terufumi, Nishio Makoto, Goto Koichi, Atagi Shinji, Hosomi Yukio, Yamamoto Noboru, Hida Toyoaki, Maemondo Makoto, Nakagawa Kazuhiko, Nagase Seisuke, Okamoto Isamu, Yamanaka Takeharu, Tajima Kosei, Harada Ryosuke, Fukuoka Masahiro, Yamamoto Nobuyuki

Abstract excerpt

BACKGROUND: With use of EGFR tyrosine-kinase inhibitor monotherapy for patients with activating EGFR mutation-positive non-small-cell lung cancer (NSCLC), median progression-free survival has been extended to about 12 months. Nevertheless, new strategies are needed to further extend progression-free survival and overall survival with acceptable toxicity and tolerability for this population. We aimed to compare...

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PMID: 25175099
DOI: 10.1016/S1470-2045(14)70381-X

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EGFR

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