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Article

Multilevel proteomic analyses reveal molecular diversity between diffuse-type and intestinal-type gastric cancer.

Nature communications - 14 Feb 2023

Shi Wenhao, Wang Yushen, Xu Chen, Li Yan, Ge Sai, Bai Bin, Zhang Kecheng, Wang Yunzhi, Zheng Nairen, Wang Juan, Wang Shiqi, Ji Gang, Li Jipeng, Nie Yongzhan, Liang Wenquan, Wu Xiaosong, Cui Jianxin, Wang Yi, Chen Lin, Zhao Qingchuan, Shen Lin, He Fuchu, Qin Jun, Ding Chen

Abstract excerpt

Diffuse-type gastric cancer (DGC) and intestinal-type gastric cancer (IGC) are the major histological types of gastric cancer (GC). The molecular mechanism underlying DGC and IGC differences are poorly understood. In this research, we carry out multilevel proteomic analyses, including proteome, phospho-proteome, and transcription factor (TF) activity profiles, of 196 cases covering DGC and IGC in Chinese...

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Identifiers

PMID: 36788224
DOI: 10.1038/s41467-023-35797-6
PMCID: PMC9929250

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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