Article
European standard clinical practice - Key issues for the medical care of individuals with familial leukemia.
European journal of medical genetics - 1 Apr 2023
Förster Alisa, Davenport Claudia, Duployez Nicolas, Erlacher Miriam, Ferster Alina, Fitzgibbon Jude, Göhring Gudrun, Hasle Henrik, Jongmans Marjolijn C, Kolenova Alexandra, Kronnie Geertruijte, Lammens Tim, Mecucci Cristina, Mlynarski Wojciech, Niemeyer Charlotte M, Sole Francesc, Szczepanski Tomasz, Waanders Esmé, Biondi Andrea, Wlodarski Marcin, Schlegelberger Brigitte, Ripperger Tim
Abstract excerpt
Although hematologic malignancies (HM) are no longer considered exclusively sporadic, additional awareness of familial cases has yet to be created. Individuals carrying a (likely) pathogenic germline variant (e.g., in ETV6, GATA2, SAMD9, SAMD9L, or RUNX1) are at an increased risk for developing HM. Given the clinical and psychological impact associated with the diagnosis of a genetic predisposition to HM, it is...
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