Article
Fusion of Wild-Type Mesoangioblasts with Myotubes of mtDNA Mutation Carriers Leads to a Proportional Reduction in mtDNA Mutation Load.
International journal of molecular sciences - 31 Jan 2023
Zelissen Ruby, Ahmadian Somaieh, Montilla-Rojo Joaquin, Timmer Erika, Ummelen Monique, Hopman Anton, Smeets Hubert, van Tienen Florence
Abstract excerpt
In 25% of patients with mitochondrial myopathies, pathogenic mitochondrial DNA (mtDNA) mutation are the cause. For heteroplasmic mtDNA mutations, symptoms manifest when the mutation load exceeds a tissue-specific threshold. Therefore, lowering the mutation load is expected to ameliorate disease manifestations. This can be achieved by fusing wild-type mesoangioblasts with mtDNA mutant myotubes. We have tested this...
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