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Article

Endothelial Cell Phenotypes Demonstrate Different Metabolic Patterns and Predict Mortality in Trauma Patients.

International journal of molecular sciences - 23 Jan 2023

Henriksen Hanne H, Marín de Mas Igor, Nielsen Lars K, Krocker Joseph, Stensballe Jakob, Karvelsson Sigurður T, Secher Niels H, Rolfsson Óttar, Wade Charles E, Johansson Pär I

Abstract excerpt

In trauma patients, shock-induced endotheliopathy (SHINE) is associated with a poor prognosis. We have previously identified four metabolic phenotypes in a small cohort of trauma patients (N = 20) and displayed the intracellular metabolic profile of the endothelial cell by integrating quantified plasma metabolomic profiles into a genome-scale metabolic model (iEC-GEM). A retrospective observational study of 99...

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PMID: 36768579
DOI: 10.3390/ijms24032257
PMCID: PMC9916682

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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