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The members of the miR-148/152 family inhibit cancer stem cell-like properties in gastric cancer via negative regulation of ITGA5

10 Feb 2023

Abstract excerpt

BACKGROUND: The role of microRNA (miRNA) in modulating the function of cancer stem cells through diverse signaling pathway has been evidenced. We here identified a role of microRNA (miRNA) family, specifically miR-148/152, in gastric cancer and delineated its functional effects on gastric cancer stem cells. METHODS: EpCAM (high) cells sorted from AGS cells subjected to gain-of-function experiments, followed by...

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PMID: 36765401
DOI: 10.1186/s12967-023-03894-1

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