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Article

Mutation Spectrum in Liquid Versus Solid Biopsies From Patients With Advanced Gastroenteropancreatic Neuroendocrine Carcinoma.

JCO precision oncology - 1 Feb 2023

Knappskog Stian, Grob Tobias, Venizelos Andreas, Amstutz Ursula, Hjortland Geir O, Lothe Inger M, Kersten Christian, Hofsli Eva, Sundlöv Anna, Elvebakken Hege, Garresori Herish, Couvelard Anne, Svensson Johanna, Sorbye Halfdan, Perren Aurel

Abstract excerpt

PURPOSE: Gastroenteropancreatic neuroendocrine carcinomas (GEP-NEC) are rare and have a poor prognosis. Most GEP-NEC are diagnosed with metastatic disease, with only minor biopsies available for molecular diagnostics. We assessed the applicability of liquid biopsies for molecular profiling of GEP-NEC. MATERIALS AND METHODS: We performed massive parallel sequencing of 76 cancer-related genes in circulating tumor...

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Identifiers

PMID: 36753687
DOI: 10.1200/PO.22.00336
PMCID: PMC9928986

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