Article
Split k-mer analysis compared to cgMLST and SNP-based core genome analysis for detecting transmission of vancomycin-resistant enterococci: results from routine outbreak analyses across different hospitals and hospitals networks in Berlin, Germany.
Microbial genomics - 1 Jan 2023
Maechler Friederike, Weber Anna, Schwengers Oliver, Schwab Frank, Denkel Luisa, Behnke Michael, Gastmeier Petra, Kola Axel
Abstract excerpt
The increase of Vancomycin-resistant Enterococcus faecium (VREfm) in recent years has been partially attributed to the rise of specific clonal lineages, which have been identified throughout Germany. To date, there is no gold standard for the interpretation of genomic data for outbreak analyses. New genomic approaches such as split k-mer analysis (SKA) could support cluster attribution for routine outbreak...
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